Dogs who spend a lot of time outdoors or hunting dogs may occasionally develop a toe cyst. Toe cysts are painful, infected, and most commonly the result of trauma to the toe regions or an entrapped foreign body such as a grass seed or awn. A skin mite can also cause it. Toe cysts usually need antibiotics and possible surgery to remove any foreign body. First aid will relieve discomfort and aid in recovery however it is important to seek veterinary attention.